Using the historical U.S. EPA 1986 weight-of-evidence classification for…
2024
Using the historical U.S. EPA 1986 weight-of-evidence classification for carcinogenicity, match List I with List II.
List I: Toxic-substance group | List II: Carcinogenicity category |
|---|---|
A. Group A | I. Probable Human Carcinogen |
B. Group B | II. Not Classifiable as to Human Carcinogenicity |
C. Group C | III. Human Carcinogen |
D. Group D | IV. Possible Human Carcinogen |
Choose the correct matching from the options below.
Answer: D. A–III, B–I, C–IV, D–II — ConceptA carcinogen classification scheme ranks the strength of evidence that an agent can cause cancer in humans. The historical U.S. EPA letter scheme uses…
- A.
A–II, B–IV, C–I, D–III
- B.
A–II, B–I, C–IV, D–III
- C.
A–III, B–IV, C–I, D–II
- D.
A–III, B–I, C–IV, D–II
Show answer & explanation
Correct answer: D
Concept
A carcinogen classification scheme ranks the strength of evidence that an agent can cause cancer in humans. The historical U.S. EPA letter scheme uses Groups A through E for this weight-of-evidence judgment.
Group A denotes human carcinogenicity, Group B probable human carcinogenicity, Group C possible human carcinogenicity, and Group D inadequate evidence for classification. These labels indicate certainty of evidence, not a numerical degree of toxicity.
Application
Group | EPA category | List-II code |
|---|---|---|
A | Human Carcinogen | III |
B | Probable Human Carcinogen | I |
C | Possible Human Carcinogen | IV |
D | Not Classifiable as to Human Carcinogenicity | II |
Cross-check and contrast
A–II would assign the strongest evidence category to the unclassifiable label.
B–IV would exchange the probable and possible evidence levels.
C–I would exchange the possible and probable evidence levels.
D–III would assign the unclassifiable category to confirmed human carcinogenicity.
Therefore, the complete matching is A–III, B–I, C–IV, D–II.