Pointing to a photo on the wall, Asha said, "His mother's only daughter is my…

Concept: In a blood-relation puzzle, first redraw each sentence as a family-tree link — replace every pronoun ("his", "my", "her") with the actual person it refers to — then read off the target relationship by counting the generation gap and the gender of the person asked about.

1. The man in the photo is male, and "his mother's only daughter" cannot be the man himself (a daughter must be female) — so this only daughter is his sister.

2. Asha says this only daughter "is my mother" — so the man's sister is Asha's mother.

3. Since the man is the brother of Asha's mother, he is Asha's maternal uncle.

4. The daughter of one's sister is one's niece, so Asha — the daughter of the man's sister — is his niece.

Cross-check: reversing the chain confirms it — the man's sister's daughter must, by definition, be his niece, matching the deduction above.

So Asha is the "niece" of the man in the photo.