The Ames test is used for determining what?
2019
The Ames test is used for determining what?
Answer: D. To estimate the carcinogenic potential of a chemical — ConceptA mutagenicity assay detects whether a substance causes heritable changes in DNA. Because mutations are one mechanism of carcinogenesis, such assays…
- A.
To measure nuclear radiation in an area
- B.
To test a patient’s physical fitness
- C.
To diagnose heart disease in a patient
- D.
To estimate the carcinogenic potential of a chemical
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Correct answer: D
Concept
A mutagenicity assay detects whether a substance causes heritable changes in DNA. Because mutations are one mechanism of carcinogenesis, such assays provide screening evidence about carcinogenic potential; they do not directly diagnose a patient or measure environmental radiation.
Application
The Ames test exposes specially engineered strains of Salmonella bacteria to a chemical and observes whether mutations restore their ability to grow without a required nutrient. An increased number of revertant colonies indicates mutagenic activity, so the test is used to estimate the chemical’s carcinogenic potential among the offered choices.
Contrast
Measuring nuclear radiation requires radiation detectors such as Geiger–Müller counters or dosimeters.
Testing physical fitness evaluates abilities such as endurance, strength, mobility, and cardiovascular response.
Diagnosing heart disease uses clinical assessment and cardiac tests such as ECG or echocardiography.
Result
Therefore, the Ames test is used to estimate the carcinogenic potential of a chemical.